The Laminin 511 / 521 – binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3 Tosti
نویسندگان
چکیده
1Bristol Institute for Transfusion Sciences (BITS), National Blood Service, Bristol, United Kingdom; 2Department of Biochemistry, University of Bristol, Bristol, United Kingdom; 3Department of Chemistry, University of Aarhus, Aarhus, Denmark; 4School of Optometry and Vision Sciences, Cardiff University, Cardiff, United Kingdom; 5New York Blood Center, New York City; and 6University of California, Lawrence Berkeley National Laboratory, Berkeley
منابع مشابه
The Laminin 511/521-binding site on the Lutheran blood group glycoprotein is located at the flexible junction of Ig domains 2 and 3.
The Lutheran blood group glycoprotein, first discovered on erythrocytes, is widely expressed in human tissues. It is a ligand for the alpha5 subunit of Laminin 511/521, an extracellular matrix protein. This interaction may contribute to vaso-occlusive events that are an important cause of morbidity in sickle cell disease. Using x-ray crystallography, small-angle x-ray scattering, and site-direc...
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The Lutheran glycoprotein (Lu), also known as basal cell adhesion molecule (B-CAM), is an Ig superfamily (IgSF) transmembrane receptor for laminin α5. Although Lu is not present in normal hepatocytes, its expression is significantly increased in hepatocellular carcinoma (HCC). In this study, we isolated thirteen phage antibodies to Lu from a phage library of peripheral blood from HCC patients, ...
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BACKGROUND The Lutheran blood group glycoprotein (Lu), an Ig superfamily (IgSF) transmembrane receptor, is also known as basal cell adhesion molecule (B-CAM). Lu/B-CAM is a specific receptor for laminin α5, a major component of basement membranes in various tissues. Previous reports have shown that Lu/B-CAM binding to laminin α5 contributes to sickle cell vaso-occlusion. However, as there are n...
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